After the murder of her lover Caesar, Egypt's queen Cleopatra needs a new ally. She seduces his probable successor Mark Antony. This develops into real love and slowly leads to a war with the other possible successor: Octavius.

Cuban leader Fidel Castro is humbled when he arrives in Miami and experiences America from the unique perspective of a typical Cuban-American in producer-turned-director Alejandro Gonzalez Padilla's clever culture shock drama.